7-hydroxy methotrexate - SAFETY DATA SHEET Page: 1 of 5 7-hydroxy Methotrexate
Professional guide for Methotrexate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Methotrexate DRUG NAME: Methotrexate SYNONYM Methotrexate is a folate antagonist. 2 Tetrahydrofolate is the active form of folic acid and 7-hydroxy
-hydroxymethotrexate is a metabolite of methotrexate. Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions.
Pharmacokinetics of Methotrexate and 7-Hydroxy-Methotrexate after High-Dose (33. 6 g/m 2) Methotrexate Therapy
The use of high-dose methotrexate (MTX) Consequently, 7-hydroxy-MTX may contribute to the renal toxicity commonly associated with high-dose therapy.
Dose-dependent Pharmacokinetics of Methotrexate and 7-Hydroxymethotrexate in 7-hydroxy-methotrexate: Dose-dependent Pharmacokinetics of Methotrexate and